منابع مشابه
Anti-Insulin Antibodies and Adverse Events with Biosimilar Insulin Lispro Compared with Humalog Insulin Lispro in People with Diabetes
BACKGROUND SAR342434 (SAR-Lis) is a biosimilar (follow-on) of insulin lispro (Humalog®; Ly-Lis). Two randomized, controlled, open-label, parallel-group, phase 3 studies were conducted to compare the efficacy and safety of SAR-Lis and Ly-Lis, both in combination with insulin glargine (Lantus®). SORELLA 1 was a 12-month study in 507 people with type 1 diabetes mellitus (T1DM); SORELLA 2 was a 6-m...
متن کاملPatient Perspectives on Biosimilar Insulin.
Given that a new wave of biosimilar insulins will likely enter the market in coming years, it is important to understand patient perspectives on these biosimilars. A survey (N = 3214) conducted by the market research company dQ&A, which maintains a 10 000-patient panel of people with type 1 or type 2 diabetes in roughly equal measure, investigated these perspectives. The survey asked whether pa...
متن کاملInsulin in blood and insulin antibodies.
T HIS presentation is concerned with the state of insulin in plasma rather than the physiologic regulation of insulin secretion. Our own studies on the concentrations of immunoassayable insulin in blood in hyperglycemic and hypoglycemic states have recently been summarized elsewhere [ 7-31. Since insulin in blood has never been extracted and recovered in amounts sufficient to permit its chemica...
متن کاملSize Exclusion Chromatography of Biosimilar and Innovator Insulin
Insulin is a small polypeptide hormone that controls blood glucose homeostasis. Genetic engineering techniques have enabled biopharma companies to develop diverse, long-acting insulin analogs. There is no pharmacopeia method available for the analysis of insulin analogs. An SEC method identifying innovator and biosimilar insulin analog, following a draft EP method, was developed using an Agilen...
متن کاملExtreme Insulin Resistance From Insulin Antibodies (Not Insulin Receptor Antibodies) Successfully Treated With Combination Immunosuppressive Therapy.
A relationship between insulin resistance (IR) and insulin antibodies (IAs) was first described in the 1950s and was thought to be due to the use of nonhuman insulins (1). Since the introduction of human insulin, the presence of IAs and consequent IR was felt to be clinically insignificant (2). The presence of high levels of IAs, associated with random hypoglycemia in insulin-naive patients, is...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Diabetes Science and Technology
سال: 2013
ISSN: 1932-2968,1932-2968
DOI: 10.1177/193229681300700401